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Although claims of superiority have been made for particular AIs with respect to bone loss 38, the LEAP Letrozole, Exemestane, and Anastrozole Pharmacodynamics trial involving 90 patients at 24 weeks of treatment showed that the steroidal and nonsteroidal AIs appear to have similar effects on bone biochemical measurements and presumably bone turnover 5 mg cialis generic india The goal of neoadjuvant therapy is to reduce the pre surgical tumor burden and increase the rate of BCS in mastectomy candidates, or allow operability of a previously inoperable tumor 18, 19